The aim of the report is to characterize new challenges and opportunities created by digital transformation in the field of higher education, the functioning of universities as research and teaching centers and organizations, as well as science and cooperation between science and business. We begin by outlining the broader context of the relationship between digital transformation and science and higher education, showing changes taking place on the labor market and concerning the growing role of digital, cognitive and social competences. We characterize the ecosystem of digital science, describe how digital transformation changes the process of studying and changes the university as an institution - both in internal and inter-university relations and with external actors from the private and public sectors. The publication ends with a list of recommendations relating to individual areas of the digital transformation of science and higher education.